Let Panic's Nova loose on a new node-based web project and it'll try and automatically index every file in the project. Including node_modules, with its 100,000+ files. This would spin up my fan and my computer's battery down to zero in no time.
Nova has a feature to prevent this. In a project's settings you can specify
node_modules as a pattern to ignore when indexing. Watch out though! You'll need to click 'Reindex all files' for it to take effect. It took me weeks to figure this out.